Reply: Cerebrospinal Fluid, Hyposmia, and Dementia in Alzheimer Disease: Insights from Dynamic PET and a Hypothesis

Title : Apolipoprotein E 4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer ' s disease

Correspondence and reprint requests to: Dr. Mitsuyasu Kanai Department of Neurology, Gunma University School of Medicine, Phone Number: +81-27-220-8061, Facsimile Number: +81-27-220-8068, E-mail: [email protected] This manuscript consists of 1811 words in text, 120 words in abstract, 1 figure, 1 table and 20 references. Brief running head title: ApoE4 declines dementia and increas...

Preanalytical variables and Alzheimer disease biomarker concentrations in cerebrospinal fluid.

Cerebrospinal fluid (CSF) -amyloid (A 1–42) is one of the key biological forms of -amyloid protein in brain tissue that inversely reflects brain amyloid burden with reduced concentrations in Alzheimer disease (AD) (1 ). Reductions in CSF A 1–42 have been shown to occur years before symptom onset (2 ) and to have good positive predictive value for progression from mild cognitive impairment to cl...

Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease.

Biomarkers to assist in the diagnosis and medical management of Alzheimer disease (AD) are a pressing need. We have employed a proteomic approach, microcapillary liquid chromatography mass spectrometry of proteins labeled with isotope-coded affinity tags (ICAT), to quantify relative changes in the proteome of human cerebrospinal fluid (CSF) obtained from the lumbar cistern. Using CSF from well-...

Cerebrospinal fluid markers in dementia with lewy bodies compared with Alzheimer disease.

BACKGROUND Most patients with dementia with Lewy bodies (DLB) exhibit diffuse plaque-only pathology with rare neocortical neurofibrillary tangles (NFTs), as opposed to the widespread cortical neurofibrillary-tau involvement in Alzheimer disease (AD). Another pathological difference is the astrocytic and microglial inflammatory responses, including release of interleukins (ILs), around the neuri...

Medical Policy Cerebrospinal Fluid and Urinary Biomarkers of Alzheimer Disease